Urinary bladder carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide in female Swiss mice.

نویسندگان

  • E Ertürk
  • S M Cohen
  • G T Bryan
چکیده

yV-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide was fed to 50 female 5-week-old Swiss mice at a dose of 0.094% by weight of diet for 46 weeks, followed by 7 weeks of the control diet. Fifty-six mice received only the control diet. Thirty-three test mice survived 40 weeks or longer and had the following tumor incidences: urinary bladder, 31/33; generalized leukemia, 23/33; lung, 6/33; and 1 uterine tumor. In the controls, the following tumor in cidences were found: generalized leukemia, 15/44; and lung, 1/44.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparative carcinogenicity in Swiss mice of N-(4-(5-nitro-2-furyl)-2-thiazolyl)acetamide and structurally related 5-nitrofurans and 4-nitrobenzenes.

Aq4{5-Nitro-2-furyl)-2-thiazolyl]acetamide (NFTA), fed to female Swiss mice at doses of 0.05 and 0.1% of the diet, induced a high incidence of lymphocytic leukemia and a low incidence of forestomach tumors. Several other chemicals structurally related to NFTA were also fed to female Swiss mice to determine structure-activity relationships with respect to organ specificity. 7V-[4-(5-Nitro-2-fury...

متن کامل

Temporal comparisons of immune status and target organ histology in mice fed carcinogenic 5-nitrofurans and their nornitro analogs.

Immune status and target organ histology were temporally evaluated in mice fed either carcinogenic 5-nitrofurans or their noncarcinogenic nornitro analogs. Mice were fed either the leukemogen A/-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide (NFTA) or the urinary bladder carcinogen A/-[4-(5-nitro-2-furyl)2-thiazolyl]formamide or their nornitro analogs, A/-[4-(2-furyl)2-thiazolyl]acetamide or A/-{4-...

متن کامل

Nornitro Analogs Histology in Mice Fed Carcinogenic 5-Nitrofurans and Their Temporal Comparisons of Immune Status and Target Organ

Immune status and target organ histology were temporally evaluated in mice fed either carcinogenic 5-nitrofurans or their noncarcinogenic nornitro analogs. Mice were fed either the leukemogen A/-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide (NFTA) or the urinary bladder carcinogen A/-[4-(5-nitro-2-furyl)2-thiazolyl]formamide or their nornitro analogs, A/-[4-(2-furyl)2-thiazolyl]acetamide or A/-{4-...

متن کامل

Effect of avitaminosis A and hypervitaminosis A on urinary bladder carcinogenicity of N-(4-(5-Nitro-2-furyl)-2-thiazolyl)formamide.

The effect of vitamin A deficiency and hypervitaminosis A on the urothelial carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formanmide (FANFT) was determined in female weanling Sprague-Dawley rats. Vitamin A deficiency resulted in squamous metaplasia of the urinary bladder and high incidences of cystitis, ureteritis, and pyelonephritis. Administration of FANFT to vitamin A-deficient rats ...

متن کامل

Effect of peroxidase inhibitors on an in vivo metabolite of the urinary bladder carcinogen N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide in rats.

Peroxidase metabolism of 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT) was evaluated in vitro and in vivo. In vitro metabolism of ANFT was characteristic of the hydroperoxidase activity of prostaglandin H synthase. The peroxidase inhibitors, 6-n-propyl-2-thiouracil and methimazole, significantly reduced ANFT binding to trichloroacetic acid precipitable material and glutathione conjugate formation....

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Cancer research

دوره 30 5  شماره 

صفحات  -

تاریخ انتشار 1970